MDH1

MDH1
Identifiers
Aliases	MDH1, HEL-S-32, MDH-s, MDHA, MGC:1375, MOR2, malate dehydrogenase 1
External IDs	MGI: 97051 HomoloGene: 4324 GeneCards: MDH1
EC number	1.1.1.96
Gene location (Human) Chr. Chromosome 2 (human) Band 2p15 Start 63,588,609 bp End 63,607,197 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band n/a Start 21,556,787 bp End 21,572,367 bp
Gene ontology Molecular function • malic enzyme activity • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • oxidoreductase activity • protein binding • diiodophenylpyruvate reductase activity • malate dehydrogenase activity • NAD binding • catalytic activity • L-malate dehydrogenase activity Cellular component • extracellular exosome • myelin sheath • extracellular space • cytoplasm • mitochondrion • cytosol Biological process • gluconeogenesis • NAD metabolic process • carboxylic acid metabolic process • oxidation-reduction process • Q14762260 • tricarboxylic acid cycle • oxaloacetate metabolic process • malate metabolic process • NADH metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4190	17449
Ensembl	ENSG00000014641	ENSMUSG00000020321
UniProt	P40925	P14152
RefSeq (mRNA)	NM_005917 NM_001199111 NM_001199112 NM_001316374	NM_008618 NM_001316675
RefSeq (protein)	NP_001186040 NP_001186041 NP_001303303 NP_005908	NP_001303604 NP_032644
Location (UCSC)	Chr 2: 63.59 – 63.61 Mb	Chr 2: 21.56 – 21.57 Mb
PubMed search

4190

17449

ENSG00000014641

ENSMUSG00000020321

P40925

P14152

NM_005917
NM_001199111
NM_001199112
NM_001316374

NM_008618
NM_001316675

NP_001186040
NP_001186041
NP_001303303
NP_005908

NP_001303604
NP_032644

Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an enzyme that in humans is encoded by the MDH1 gene.

Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Wikipedia