MBD3

MBD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2MB7
Identifiers
Aliases	MBD3
External IDs	MGI: 1333812 HomoloGene: 2917 GeneCards: MBD3
Gene ontology Molecular function • methyl-CpG binding • DNA binding • nucleosomal DNA binding • RNA polymerase II distal enhancer sequence-specific DNA binding • protein binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • chromatin binding • histone deacetylase activity Cellular component • nucleus • nucleoplasm • protein complex • nuclear chromatin • heterochromatin • chromosome • NuRD complex • cytoplasm • chromatin Biological process • response to estradiol • tissue development • embryonic organ development • regulation of DNA methylation • in utero embryonic development • response to organic cyclic compound • regulation of transcription, DNA-templated • ATP-dependent chromatin remodeling • heart development • methylation-dependent chromatin silencing • histone acetylation • negative regulation of transcription from RNA polymerase II promoter • aging • brain development • response to nutrient levels • transcription, DNA-templated • regulation of signal transduction by p53 class mediator • histone deacetylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	53615	17192
Ensembl	ENSG00000071655	ENSMUSG00000035478
UniProt	O95983	Q9Z2D8
RefSeq (mRNA)	NM_003926 NM_001281453 NM_001281454	NM_013595 NM_001306143
RefSeq (protein)	NP_001268382 NP_001268383	NP_001293072.1 NP_038623.1 NP_001293072 NP_038623
Location (UCSC)	Chr 19: 1.57 – 1.59 Mb	Chr 10: 80.39 – 80.4 Mb
PubMed search

2MB7

53615

17192

ENSG00000071655

ENSMUSG00000035478

O95983

Q9Z2D8

NM_003926
NM_001281453
NM_001281454

NM_013595
NM_001306143

NP_001268382
NP_001268383

NP_001293072.1
NP_038623.1
NP_001293072
NP_038623

Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA but instead binds to hydroxymethylated DNA [1]. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.

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Wikipedia