MBD2

MBD2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L2L
Identifiers
Aliases	MBD2, DMTase, NY-CO-41, methyl-CpG binding domain protein 2
External IDs	MGI: 1333813 HomoloGene: 2918 GeneCards: MBD2
Gene ontology Molecular function • RNA polymerase II distal enhancer sequence-specific DNA binding • DNA binding • protein domain specific binding • methyl-CpG binding • C2H2 zinc finger domain binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • siRNA binding • nucleosomal DNA binding • satellite DNA binding • mRNA binding Cellular component • cytoplasm • histone deacetylase complex • protein complex • heterochromatin • chromatin • nucleus • nuclear chromatin • nucleoplasm • cytosol Biological process • regulation of transcription, DNA-templated • cellular protein complex assembly • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • ATP-dependent chromatin remodeling • positive regulation of Wnt signaling pathway • regulation of cell proliferation • maternal behavior • negative regulation of transcription, DNA-templated • aging • response to mechanical stimulus • response to estradiol • cellular response to organic cyclic compound • response to nutrient levels • response to organic cyclic compound • positive regulation of chromatin binding • heart development • embryonic organ development • chromatin silencing at rDNA • regulation of DNA methylation • methylation-dependent chromatin silencing Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8932	17191
Ensembl	ENSG00000134046	ENSMUSG00000024513
UniProt	Q9UBB5	Q9Z2E1
RefSeq (mRNA)	NM_015832 NM_003927	NM_010773 NM_001311071
RefSeq (protein)	NP_003918 NP_056647 NP_056647.1	NP_001298000 NP_034903
Location (UCSC)	Chr 18: 54.15 – 54.22 Mb	Chr 18: 70.57 – 70.63 Mb
PubMed search

2L2L

8932

17191

ENSG00000134046

ENSMUSG00000024513

Q9UBB5

Q9Z2E1

NM_015832
NM_003927

NM_010773
NM_001311071

NP_003918
NP_056647
NP_056647.1

NP_001298000
NP_034903

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1, and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing if present in promoter regions.

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Wikipedia