MASP1 (protein)

MASP1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3DEM, 3GOV, 4AQB, 4DJZ, 4IGD, 4IW4, 4KKD
Identifiers
Aliases	MASP1, 3MC1, CRARF, CRARF1, MAP1, MASP, MASP3, MAp44, PRSS5, RaRF, mannan binding lectin serine peptidase 1
External IDs	OMIM: 600521 HomoloGene: 89143 GeneCards: MASP1
Gene ontology Molecular function • calcium ion binding • peptidase activity • serine-type peptidase activity • protein binding • hydrolase activity • protein homodimerization activity • calcium-dependent protein binding • metal ion binding • serine-type endopeptidase activity Cellular component • extracellular region • extracellular space • nucleoplasm • cytosol Biological process • complement activation, lectin pathway • receptor-mediated endocytosis • proteolysis • negative regulation of complement activation • immune system process • innate immune response • complement activation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5648	n/a
Ensembl	ENSG00000127241	n/a
UniProt	P48740	n/a
RefSeq (mRNA)	NM_001031849 NM_001879 NM_139125	n/a
RefSeq (protein)	NP_001027019 NP_001870 NP_624302	n/a
Location (UCSC)	Chr 3: 187.22 – 187.29 Mb	n/a
PubMed search		n/a

3DEM, 3GOV, 4AQB, 4DJZ, 4IGD, 4IW4, 4KKD

5648

n/a

ENSG00000127241

n/a

P48740

n/a

NM_001031849
NM_001879
NM_139125

n/a

NP_001027019
NP_001870
NP_624302

n/a

Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 (MASP-1) is an enzyme that in humans is encoded by the MASP1 gene.

MASP-1 is involved in the lectin pathway of the complement system and is responsible for cleaving C4 and C2 to form C4b2a, a C3-convertase.

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