Complement component 2

C2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I6S, 3ERB,%%s2ODQ
Identifiers
Aliases	C2, ARMD14, CO2, complement component 2
External IDs	MGI: 88226 HomoloGene: 45 GeneCards: C2
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • hydrolase activity • metal ion binding • serine-type endopeptidase activity • protein binding Cellular component • extracellular region • extracellular exosome • extracellular space Biological process • complement activation • positive regulation of apoptotic cell clearance • regulation of complement activation • response to nutrient • proteolysis • complement activation, classical pathway • immune system process • innate immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	717	12263
Ensembl	n/a	ENSMUSG00000024371
UniProt	P06681 Q5JP69	P21180
RefSeq (mRNA)	NM_000063 NM_001145903 NM_001178063 NM_001282457 NM_001282458 NM_001282459	NM_013484
RefSeq (protein)	NP_000054 NP_001139375 NP_001171534 NP_001269386 NP_001269387 NP_001269388 NP_000054.2	NP_038512.2 NP_038512
Location (UCSC)	Chr 6: 31.9 – 31.95 Mb	Chr 17: 34.86 – 34.9 Mb
PubMed search

2I6S, 3ERB,%%s2ODQ

717

12263

n/a

ENSMUSG00000024371

P06681
Q5JP69

P21180

NM_001282459

NM_013484

NP_001269388
NP_000054.2

NP_038512.2
NP_038512

Complement C2 is a protein that in humans is encoded by the C2 gene. The protein encoded by this gene is part of the classical pathway of complement system, acting as a multi-domain serine protease. Deficiency of C2 has been associated with certain autoimmune diseases.

In the classical and lectin pathways of complement activation, formation of the C3-convertase and C5-convertases requires binding of C2 to an activated surface-bound C4b in the presence of Mg²⁺; the resultant C4bC2 complex is then cleaved by C1s or MASP2 into C2a and C2b. It is thought that cleavage of C2 by C1s, while bound to C4b. results into a conformational rotation of C2a whereas the released C2b fragment may retain most of its original structure. C2a is the larger, enzymatically active fragment which is incorporated into the C3 convertase in this pathway, C4b2. C2b is released into the fluid phase.

...
Wikipedia