MAFB (gene)

MAFB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WT7, 2WTY, 4AUW
Identifiers
Aliases	MAFB, KRML, MCTO, MAF bZIP transcription factor B, DURS3
External IDs	MGI: 104555 HomoloGene: 31315 GeneCards: MAFB
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding Cellular component • transcription factor complex • nucleus Biological process • T cell differentiation in thymus • negative regulation of osteoclast differentiation • brain segmentation • thymus development • transcription from RNA polymerase II promoter • respiratory gaseous exchange • segment specification • negative regulation of erythrocyte differentiation • nervous system development • GO:0006350 transcription, DNA-templated • rhombomere 6 development • rhombomere 5 development • inner ear morphogenesis • sensory organ development • positive regulation of transcription from RNA polymerase II promoter • regulation of transcription, DNA-templated • abducens nerve formation • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9935	16658
Ensembl	ENSG00000204103	ENSMUSG00000074622
UniProt	Q9Y5Q3	P54841
RefSeq (mRNA)	NM_005461	NM_010658
RefSeq (protein)	NP_005452	NP_034788.1 NP_034788
Location (UCSC)	Chr 20: 40.69 – 40.69 Mb	Chr 2: 160.36 – 160.37 Mb
PubMed search

2WT7, 2WTY, 4AUW

9935

16658

ENSG00000204103

ENSMUSG00000074622

Q9Y5Q3

P54841

NM_005461

NM_010658

NP_005452

NP_034788.1
NP_034788

Transcription factor MafB also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B is a protein that in humans is encoded by the MAFB gene. This gene maps to chromosome 20q11.2-q13.1, consists of a single exon and spans around 3 kb.

MafB is a basic leucine zipper (bZIP) transcription factor that plays an important role in the regulation of lineage-specific hematopoiesis. The encoded nuclear protein represses ETS1-mediated transcription of erythroid-specific genes in myeloid cells.

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Wikipedia