Lymphotoxin alpha

LTA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1TNR, 4MXV, 4MXW
Identifiers
Aliases	LTA, LT, TNFB, TNFSF1, Lymphotoxin alpha, TNLG1E
External IDs	MGI: 104797 HomoloGene: 497 GeneCards: LTA
Gene ontology Molecular function • cytokine activity • tumor necrosis factor receptor binding • receptor binding Cellular component • membrane • plasma membrane • extracellular region • extracellular space Biological process • positive regulation of chronic inflammatory response to antigenic stimulus • response to hypoxia • negative regulation of growth of symbiont in host • response to nutrient • cell-cell signaling • positive regulation of humoral immune response mediated by circulating immunoglobulin • positive regulation of interferon-gamma production • tumor necrosis factor-mediated signaling pathway • response to lipopolysaccharide • humoral immune response • immune response • positive regulation of apoptotic process • lymph node development • positive regulation of glial cell proliferation • negative regulation of fibroblast proliferation • response to drug • signal transduction • defense response to Gram-positive bacterium • apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4049	16992
Ensembl	n/a	ENSMUSG00000024402
UniProt	P01374	P09225
RefSeq (mRNA)	NM_000595 NM_001159740	NM_010735
RefSeq (protein)	NP_000586 NP_001153212	NP_034865.1 NP_034865
Location (UCSC)	Chr 6: 31.57 – 31.57 Mb	Chr 17: 35.2 – 35.21 Mb
PubMed search

1TNR, 4MXV, 4MXW

4049

16992

n/a

ENSMUSG00000024402

P01374

P09225

NM_000595
NM_001159740

NM_010735

NP_000586
NP_001153212

NP_034865.1
NP_034865

Lymphotoxin-alpha (LT-alpha) or tumor necrosis factor-beta (TNF-β) is a protein that in humans is encoded by the LTA gene.

Lymphotoxin alpha, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. LTA is highly inducible, secreted, and exists as homotrimeric molecule. LTA forms heterotrimers with lymphotoxin-beta, which anchors lymphotoxin-alpha to the cell surface. LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. LTA is also involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.

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