LTB

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4MXW

Identifiers

Aliases

LTB, TNFC, TNFSF3, p33, Lymphotoxin beta, TNLG1C

External IDs

MGI: 104796 HomoloGene: 1752 GeneCards: LTB

Gene ontology
Molecular function	• tumor necrosis factor receptor binding • cytokine activity • receptor binding
Cellular component	• integral component of membrane • plasma membrane • membrane • extracellular space
Biological process	• cell-cell signaling • positive regulation of interleukin-12 biosynthetic process • tumor necrosis factor-mediated signaling pathway • lymph node development • gene expression • immune response • signal transduction • skin development
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4050


16994

Ensembl


n/a


ENSMUSG00000024399

UniProt


Q06643


P41155

RefSeq (mRNA)


NM_009588 NM_002341


NM_008518

RefSeq (protein)


NP_002332 NP_033666


NP_032544.1 NP_032544

Location (UCSC)

Chr 6: 31.58 – 31.58 Mb

Chr 17: 35.19 – 35.2 Mb

PubMed search

n/a

NP_032544.1
NP_032544

Lymphotoxin-beta (LT-beta) also known as tumor necrosis factor C (TNF-C) is a protein that in humans is encoded by the LTB gene.

Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms.

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