Lorenzo Brigham Shepard (May 27, 1821, Cairo, Greene County, New York – September 19, 1856, New York City) was an American lawyer and politician from New York.
Lorenzo B. Shepard was the son of David Brewster Shepard (1798–1835), a New York City lawyer.
At the age of 14, following the death of his parents, Shepard went to live in Oswego with his grandmother's brother David P. Brewster, a lawyer and congressman from 1839 to 1843. He studied law with Judge Ulysses D. French, was admitted to the bar in 1841, and practiced in partnership with French until 1848.
On July 5, 1842, Shepard married Lucy Morse, with whom he had five children, among them Edward Morse Shepard (1850–1911) who was the Democratic candidate for Mayor of New York City in 1901.
Lorenzo B. Shepard was a delegate to the New York State Constitutional Convention of 1846. In 1848, he was appointed by President James K. Polk as U.S. Attorney for the Southern District of New York to fill the vacancy caused by the death of Charles McVean, but was removed in 1849 by President Zachary Taylor.
Shepard was a delegate to the 1852 Democratic National Convention. On July 25, 1854, he was appointed by Gov. Horatio Seymour as New York County District Attorney to fill the vacancy caused by the death of N. Bowditch Blunt, and remained in office until the end of the year.