Loratadine
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| Clinical data | |
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| Trade names | Claritin, Claratyne, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a697038 |
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| Routes of administration |
by mouth |
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| Pharmacokinetic data | |
| Bioavailability | almost 100% |
| Protein binding | 97–99% |
| Metabolism | liver (CYP2D6- and 3A4-mediated) |
| Biological half-life | 8 hours, active metabolite desloratadine 27 hours |
| Excretion | 40% as conjugated metabolites into urine Similar amount into the feces |
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| ChEMBL | |
| ECHA InfoCard | 100.120.122 |
| Chemical and physical data | |
| Formula | C22H23ClN2O2 |
| Molar mass | 382.88 g/mol |
| 3D model (Jmol) | |
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Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. This includes allergic rhinitis (hay fever) and hives. It is also available in combination with pseudoephedrine, a decongestant, known as loratadine/pseudoephedrine. It is taken by mouth.
Common side effects include sleepiness, dry mouth, and headache. Serious side effects are rare and include allergic reactions, seizures, and liver problems. Use during pregnancy appears to be safe but has not been well studied. It is not recommended in children less than two years old. It is in the second-generation antihistamine family of medication.
Loratadine was discovered in 1981 and came to market in 1993. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. Loratadine is available as a generic medication. The wholesale cost in the developing world is about 0.01 to 0.08 USD per dose. In the United States it is available over the counter.
Loratadine is indicated for the symptomatic relief of allergy such as hay fever (allergic rhinitis), urticaria (hives), chronic idiopathic urticaria, and other skin allergies. For allergic rhinitis (hay fever), loratadine is effective for both nasal and eye symptoms: sneezing, runny nose, itchy or burning eyes.
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Wikipedia