Leptin receptor

LEPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3V6O
Identifiers
Aliases	LEPR, CD295, LEP-R, LEPRD, OB-R, OBR, leptin receptor
External IDs	MGI: 104993 HomoloGene: 1731 GeneCards: LEPR
Gene ontology Molecular function • leptin receptor activity • protein binding • identical protein binding • cytokine receptor activity • transmembrane signaling receptor activity Cellular component • integral component of membrane • membrane • receptor complex • plasma membrane • extracellular region • basolateral plasma membrane Biological process • sexual reproduction • glucose homeostasis • leptin-mediated signaling pathway • cholesterol metabolic process • negative regulation of hydrolase activity • regulation of feeding behavior • multicellular organism development • negative regulation of gluconeogenesis • cell surface receptor signaling pathway • T cell differentiation • angiogenesis • energy homeostasis • bone growth • energy reserve metabolic process • response to leptin • negative regulation of autophagy • regulation of energy homeostasis • regulation of bone remodeling • phagocytosis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3953	16847
Ensembl	ENSG00000116678	ENSMUSG00000057722
UniProt	P48357	P48356
RefSeq (mRNA)	NM_002303 NM_001003679 NM_001003680 NM_001198687 NM_001198688 NM_001198689	NM_001122899 NM_010704 NM_146146
RefSeq (protein)	NP_001003679 NP_001003680 NP_001185616 NP_001185617 NP_001185618 NP_002294	NP_001116371 NP_034834 NP_666258
Location (UCSC)	Chr 1: 65.42 – 65.64 Mb	Chr 4: 101.72 – 101.82 Mb
PubMed search

3V6O

3953

16847

ENSG00000116678

ENSMUSG00000057722

P48357

P48356

NM_001198689

NM_001122899
NM_010704
NM_146146

NP_002294

NP_001116371
NP_034834
NP_666258

Leptin receptor also known as LEP-R or OB-R is a protein that in humans is encoded by the LEPR gene. LEP-R functions as a receptor for the fat cell-specific hormone leptin. LEP-R has also been designated as CD295 (cluster of differentiation 295).

After co-discovering the Leptin gene with Jeffrey Friedman et al. in 1994, which involved a reverse genetic/positional cloning strategy to clone ob and db, Rudolph Leibel, working with collaborators at Millennium Pharmaceuticals and colleague Streamson Chua, confirmed cloning of the leptin receptor by demonstrating that an apparent leptin receptor cloned from a choroid plexus library using leptin as ligand, mapped to a physical map that included db and fa.

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