*** Welcome to piglix ***

Leptin

LEP
Leptin.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LEP, LEPD, OB, OBS, leptin
External IDs OMIM: 164160 MGI: 104663 HomoloGene: 193 GeneCards: LEP
RNA expression pattern
PBB GE LEP 207092 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000230

NM_008493

RefSeq (protein)

NP_000221

NP_032519.1
NP_032519

Location (UCSC) Chr 7: 128.24 – 128.26 Mb Chr 6: 29.06 – 29.07 Mb
PubMed search
Leptin
PDB 1ax8 EBI.jpg
Structure of the obese protein leptin-E100.
Identifiers
Symbol Leptin
Pfam PF02024
Pfam clan CL0053
InterPro IPR000065
SCOP 1ax8
SUPERFAMILY 1ax8

1AX8

NM_000230

NM_008493

NP_000221

NP_032519.1
NP_032519

Leptin (from Greek λεπτός leptos, "thin"), the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis. In obesity, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high energy stores.


...
Wikipedia

...