Leptin

LEP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AX8
Identifiers
Aliases	LEP, LEPD, OB, OBS, leptin
External IDs	OMIM: 164160 MGI: 104663 HomoloGene: 193 GeneCards: LEP
Gene ontology Molecular function • receptor binding • growth factor activity • hormone activity • peptide hormone receptor binding Cellular component • cytoplasm • extracellular region • extracellular space Biological process • regulation of protein phosphorylation • response to dietary excess • cellular response to retinoic acid • positive regulation of developmental growth • negative regulation of glucagon secretion • placenta development • cardiac muscle hypertrophy • regulation of angiogenesis • positive regulation of tyrosine phosphorylation of Stat3 protein • prostaglandin secretion • regulation of intestinal cholesterol absorption • T cell differentiation • positive regulation of reactive oxygen species metabolic process • central nervous system neuron development • circadian rhythm • positive regulation of ion transport • angiogenesis • glucose metabolic process • positive regulation of peroxisome proliferator activated receptor signaling pathway • positive regulation of hepatic stellate cell activation • regulation of endothelial cell proliferation • intestinal absorption • response to ethanol • negative regulation of autophagy • positive regulation of p38MAPK cascade • positive regulation of protein kinase B signaling • negative regulation of metabolic process • negative regulation of vasoconstriction • glucose homeostasis • regulation of insulin secretion • regulation of steroid biosynthetic process • insulin secretion • regulation of natural killer cell activation • regulation of fat cell differentiation • response to vitamin E • response to nutrient levels • bone mineralization involved in bone maturation • positive regulation of T cell proliferation • positive regulation of protein import into nucleus • regulation of brown fat cell differentiation • fatty acid beta-oxidation • regulation of metabolic process • hormone metabolic process • positive regulation of MAPK cascade • positive regulation of TOR signaling • cellular response to L-ascorbic acid • ovulation from ovarian follicle • activation of protein kinase C activity • sexual reproduction • negative regulation of cartilage development • response to nutrient • negative regulation of glutamine transport • leptin-mediated signaling pathway • bile acid metabolic process • female pregnancy • negative regulation of apoptotic process • cholesterol metabolic process • positive regulation of follicle-stimulating hormone secretion • negative regulation of transcription from RNA polymerase II promoter • negative regulation of appetite • regulation of protein localization to nucleus • regulation of blood pressure • negative regulation of glucose import • leukocyte tethering or rolling • negative regulation of lipid storage • adipose tissue development • positive regulation of insulin receptor signaling pathway • bone growth • positive regulation of JAK-STAT cascade • glycerol biosynthetic process • positive regulation of luteinizing hormone secretion • fatty acid catabolic process • regulation of gluconeogenesis • response to estradiol • intracellular signal transduction • adult feeding behavior • response to hypoxia • regulation of natural killer cell proliferation • eating behavior • positive regulation of cytokine production • regulation of cytokine production involved in inflammatory response • regulation of nitric-oxide synthase activity • response to activity • cellular response to leptin stimulus • regulation of cell cycle • regulation of natural killer cell mediated cytotoxicity • positive regulation of fat cell apoptotic process • interleukin-6 secretion • positive regulation of cell proliferation • interleukin-8 secretion • regulation of lipoprotein lipid oxidation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of myeloid cell differentiation • signal transduction • regulation of bone remodeling • lipid metabolic process • negative regulation of appetite by leptin-mediated signaling pathway • interleukin-12 production • positive regulation of tumor necrosis factor production • interleukin-6 production • response to insulin • tyrosine phosphorylation of STAT protein • phagocytosis • positive regulation of STAT protein import into nucleus • energy reserve metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3952	16846
Ensembl	ENSG00000174697	ENSMUSG00000059201
UniProt	P41159	P41160
RefSeq (mRNA)	NM_000230	NM_008493
RefSeq (protein)	NP_000221	NP_032519.1 NP_032519
Location (UCSC)	Chr 7: 128.24 – 128.26 Mb	Chr 6: 29.06 – 29.07 Mb
PubMed search

Leptin
Structure of the obese protein leptin-E100.
Identifiers
Symbol	Leptin
Pfam	PF02024
Pfam clan	CL0053
InterPro	IPR000065
SCOP	1ax8
SUPERFAMILY	1ax8
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

1AX8

3952

16846

ENSG00000174697

ENSMUSG00000059201

P41159

P41160

NM_000230

NM_008493

NP_000221

NP_032519.1
NP_032519

Leptin (from Greek λεπτός leptos, "thin"), the "satiety hormone", is a hormone made by adipose cells that helps to regulate energy balance by inhibiting hunger. Leptin is opposed by the actions of the hormone ghrelin, the "hunger hormone". Both hormones act on receptors in the arcuate nucleus of the hypothalamus to regulate appetite to achieve energy homeostasis. In obesity, a decreased sensitivity to leptin occurs, resulting in an inability to detect satiety despite high energy stores.