Ghrelin

GHRL

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1P7X

Identifiers

GHRL, MTLRP, ghrelin/obestatin prepropeptide

External IDs

MGI: 1930008 HomoloGene: 9487 GeneCards: GHRL

Gene ontology
Molecular function	• protein tyrosine kinase activator activity • hormone activity • protein binding • ghrelin receptor binding • G-protein coupled receptor binding • growth hormone-releasing hormone activity
Cellular component	• postsynapse • cytoplasm • endoplasmic reticulum lumen • extracellular region • axon • secretory granule lumen • extracellular space
Biological process	• positive regulation of appetite • negative regulation of interleukin-6 biosynthetic process • G-protein coupled receptor signaling pathway • negative regulation of interleukin-1 beta production • positive regulation of cortisol secretion • positive regulation of growth hormone receptor signaling pathway • negative regulation of insulin secretion • gastric acid secretion • positive regulation of cytosolic calcium ion concentration • dendrite development • regulation of response to food • negative regulation of energy homeostasis • negative regulation of apoptotic process • positive regulation of corticotropin secretion • negative regulation of locomotion • cortisol secretion • response to estrogen • negative regulation of endothelial cell proliferation • positive regulation of circadian sleep/wake cycle, non-REM sleep • negative regulation of tumor necrosis factor biosynthetic process • cartilage development • activation of MAPK activity • decidualization • regulation of cell proliferation • growth hormone secretion • positive regulation of energy homeostasis • positive regulation of growth hormone secretion • excitatory postsynaptic potential • hormone-mediated signaling pathway • glucose metabolic process • positive regulation of multicellular organism growth • negative regulation of angiogenesis • response to hormone • actin polymerization or depolymerization • positive regulation of response to food • negative regulation of circadian sleep/wake cycle, REM sleep • negative regulation of inflammatory response • positive regulation of insulin secretion • positive regulation of synapse assembly • positive regulation of protein tyrosine kinase activity • adult feeding behavior
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


51738


58991


ENSG00000157017


ENSMUSG00000064177


Q9UBU3


Q9EQX0

RefSeq (mRNA)

NM_001134941 NM_001134944 NM_001134945 NM_001134946 NM_001302821
NM_001302822 NM_001302823 NM_001302824 NM_001302825 NM_016362


NM_021488 NM_001286404 NM_001286405 NM_001286406

RefSeq (protein)

NP_001128413 NP_001128416 NP_001128417 NP_001128418 NP_001289750
NP_001289751 NP_001289752 NP_001289753 NP_001289754 NP_057446

NP_001273333.1 NP_001273334.1 NP_001273335.1 NP_067463.2 NP_001273333
NP_001273334 NP_001273335 NP_067463

Location (UCSC)

Chr 3: 10.29 – 10.29 Mb

Chr 6: 113.72 – 113.72 Mb

PubMed search

ENSG00000157017

ENSMUSG00000064177

NM_001302822
NM_001302823
NM_001302824
NM_001302825
NM_016362

NM_021488
NM_001286404
NM_001286405
NM_001286406

NP_001289751
NP_001289752
NP_001289753
NP_001289754
NP_057446

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Wikipedia

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