Legio quarta Scythica ("Scythian Fourth Legion") was a legion of the Imperial Roman army founded c. 42 BC by the general Mark Antony, for his campaign against the Parthian Empire, hence its other cognomen, Parthica. The legion was still active in Syria in the early 5th century.
In its first years, the whereabouts of IV Scythica are uncertain, although it is probable that it took part in Antony's campaign against the Parthians. The name suggests that it fought against the Scythians.
After the battle of Actium and Antony's suicide, Octavian transferred IV Scythica to the Danube province of Moesia. The legion is reported to have taken part in civilian tasks, such as the building and keeping of roads. In his youth, future emperor Vespasian served in this legion.
King Vologases I of Parthia invaded Armenia, a client kingdom of Rome, in 58. Nero ordered Gnaeus Domitius Corbulo, the new legate of Cappadocia, to manage the matter. Corbulo brought IIII Scythica from Moesia, and with III Gallica and VI Ferrata defeated the Parthians, restoring Tigranes VI on Armenian throne. In 62, IIII Scythica and XII Fulminata, commanded by the new legate of Cappadocia, Lucius Caesennius Paetus, were defeated by the Parthians at the Battle of Rhandeia and forced to surrender. The legions were covered with shame and removed from the war theatre to Zeugma. This city would be the base camp of IIII Scythica for the next century.