Lagovirus
| Lagovirus | |
|---|---|
| Virus classification | |
| Group: | Group IV ((+)ssRNA) |
| Family: | Caliciviridae |
| Genus: | Lagovirus |
| Type Species | |
Lagovirus is a genus of viruses, in the family Caliciviridae. Lagomorphs serve as natural hosts. There are currently only two species in this genus including the type species Rabbit hemorrhagic disease virus. Diseases associated with this genus include: necrotizing hepatitis leading to fatal hemorrhages.
Group: ssRNA(+)
Virions consist of a capsid. Virus capsid is not enveloped, round with T=3 icosahedral symmetry. The isometric capsid has a diameter of 35–39 nm. Particles with T=1 symmetry, composed of 60 capsid proteins are also observed, which have diameter of about 15 nm. Capsids appear round to hexagonal in outline. The capsid surface structure reveals a regular pattern with distinctive features. The capsomer arrangement is clearly visible. Capsid with 32 cup-shaped depressions.
Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment to host receptors, which mediates endocytosis. Replication follows the positive stranded RNA virus replication model. Positive stranded RNA virus transcription is the method of transcription. Translation takes place by RNA termination-reinitiation. Lagomorphs serve as the natural host.
The molecular mass (Mr) of virions is 15×106. Virions have a buoyant density in Caesium chloride (CsCl) of 1.33–1.36 g/cm3. The density gradient of virions in Potassium Tartrate-Glycerol is 1.29 g/cm3. The sedimentation coefficient is 170–187 svedberg (s20,w); of the other(s) are peak 160–170 svedberg (s20,w) (believed to consist of defective interfering particles). Under in vitro conditions virions are inactivated in acid environment of pH 4.5–7; stable in alkaline environment of pH 7–10.5. Virions are not stable at raised temperature in presence of high concentration of Mg++. Virions are sensitive to treatment with trypsin (in some strains, not sensitive to treatment with mild detergents, or ether, or chloroform. The infectivity is enhanced after treatment with trypsin (in some strains).
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