LYVE1

Identifiers

LYVE1, CRSBP-1, HAR, LYVE-1, XLKD1, lymphatic vessel endothelial hyaluronan receptor 1

External IDs

MGI: 2136348 HomoloGene: 4868 GeneCards: LYVE1

Gene ontology
Molecular function	• protein binding • hyaluronic acid binding • transmembrane signaling receptor activity • receptor activity
Cellular component	• integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular exosome • cell periphery
Biological process	• movement of cell or subcellular component • hyaluronan catabolic process • anatomical structure morphogenesis • cell adhesion • response to wounding • glycosaminoglycan catabolic process • cell-matrix adhesion • signal transduction • transport
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


10894


114332

Ensembl


ENSG00000133800


ENSMUSG00000030787

UniProt


Q9Y5Y7


Q8BHC0

RefSeq (mRNA)


NM_006691


NM_053247

RefSeq (protein)


NP_006682


NP_444477

Location (UCSC)

Chr 11: 10.56 – 10.61 Mb

Chr 7: 110.85 – 110.86 Mb

PubMed search

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor. In humans it is encoded by the LYVE1 gene.

LYVE1 is a type I integral membrane glycoprotein. It acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE-1 is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, allowing for the isolation of these cells for experimental purposes. The physiological role for this receptor is still the subject of debate, but evolutionary conservation suggests an important role.

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Wikipedia