LYPLA1

LYPLA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FJ2
Identifiers
Aliases	LYPLA1, APT-1, APT1, LPL-I, LPL1, hAPT1, lysophospholipase I
External IDs	MGI: 1344588 HomoloGene: 100781 GeneCards: LYPLA1
Gene location (Human) Chr. Chromosome 8 (human) Band No data available Start 54,046,367 bp End 54,102,017 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band No data available Start 4,807,788 bp End 4,848,410 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • lysophospholipase activity • hydrolase activity • lipase activity • palmitoyl-(protein) hydrolase activity • protein binding Cellular component • cytoplasm • cytosol • extracellular exosome • mitochondrion Biological process • protein depalmitoylation • regulation of nitric-oxide synthase activity • negative regulation of Golgi to plasma membrane protein transport • fatty acid metabolic process • lipid metabolic process • metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10434	18777
Ensembl	ENSG00000120992	ENSMUSG00000025903
UniProt	O75608 Q6IAQ1	P97823
RefSeq (mRNA)	NM_001279356 NM_001279357 NM_001279358 NM_001279359 NM_001279360 NM_006330	NM_008866
RefSeq (protein)	NP_001266285 NP_001266286 NP_001266287 NP_001266288 NP_001266289 NP_006321 NP_006321.1	NP_032892
Location (UCSC)	Chr 8: 54.05 – 54.1 Mb	Chr 8: 4.81 – 4.85 Mb
PubMed search

1FJ2

10434

18777

ENSG00000120992

ENSMUSG00000025903

O75608
Q6IAQ1

P97823

NM_006330

NM_008866

NP_006321
NP_006321.1

NP_032892

Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene.

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet.

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