KvLQT3

KCNQ3
Identifiers
Aliases	KCNQ3, BFNC2, EBN2, KV7.3, potassium voltage-gated channel subfamily Q member 3
External IDs	OMIM: 602232 MGI: 1336181 HomoloGene: 20949 GeneCards: KCNQ3
Genetically Related Diseases
coronary artery disease
Targeted by Drug
ezogabine, tetraethylammonium
Gene ontology Molecular function • potassium channel activity • voltage-gated ion channel activity • calmodulin binding • ion channel activity • voltage-gated potassium channel activity Cellular component • membrane • voltage-gated potassium channel complex • plasma membrane • node of Ranvier • cell surface • axon initial segment • integral component of membrane Biological process • membrane hyperpolarization • regulation of ion transmembrane transport • ion transport • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • transport • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3786	110862
Ensembl	ENSG00000184156	ENSMUSG00000056258
UniProt	O43525	Q8K3F6
RefSeq (mRNA)	NM_001204824 NM_004519	NM_152923
RefSeq (protein)	NP_001191753 NP_004510	NP_690887.2 NP_690887
Location (UCSC)	Chr 8: 132.12 – 132.48 Mb	Chr 15: 65.99 – 66.29 Mb
PubMed search

3786

110862

ENSG00000184156

ENSMUSG00000056258

O43525

Q8K3F6

NM_001204824
NM_004519

NM_152923

NP_001191753
NP_004510

NP_690887.2
NP_690887

K_v7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.

It is associated with benign familial neonatal epilepsy.

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).

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Wikipedia