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Klf4

KLF4
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
External IDs MGI: 1342287 HomoloGene: 3123 GeneCards: KLF4
RNA expression pattern
PBB GE KLF4 221841 s at fs.png

PBB GE KLF4 220266 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001314052
NM_004235

NM_010637

RefSeq (protein)

NP_001300981
NP_004226

NP_034767.2
NP_034767

Location (UCSC) Chr 9: 107.48 – 107.49 Mb Chr 4: 55.53 – 55.53 Mb
PubMed search

2WBS, 2WBU, 4M9E

NM_001314052
NM_004235

NM_010637

NP_001300981
NP_004226

NP_034767.2
NP_034767

Kruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a zinc-finger transcription factor, and it was first identified in 1996. KLF4 is a member of the KLF family of transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including Colorectal cancer. It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).


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Wikipedia

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