Kizzuwatna (or Kizzuwadna; in Ancient Egyptian Kode), is the name of an ancient Anatolian kingdom in the 2nd millennium BC. It was situated in the highlands of southeastern Anatolia, near the Gulf of İskenderun in modern-day Turkey. It encircled the Taurus Mountains and the Ceyhan river. The center of the kingdom was the city of Kummanni, situated in the highlands. In a later era, the same region was known as Cilicia.
The country possessed valuable resources, such as silver mines in the Taurus Mountains. The slopes of the mountain range are still partly covered by woods. Annual winter rains made agriculture possible in the area at a very early date (see Çatal Hüyük). The plains at the lower course of the Ceyhan river provided rich cultivated fields.
Several ethnic groups coexisted in the Kingdom of Kizzuwatna. The Hurrians inhabited this area at least since the beginning of the 2nd millennium BC. The Hittite expansion in the early Old Kingdom period (under Hattusili I and Mursili I) was likely to bring the Hittites and the Luwians to southeastern Anatolia. The Luwian language was part of the Indo-European language group, with close ties to the Hittite language. Both the local Hittites and the Luwians were likely to contribute to the formation of independent Kizzuwatna after the weakening of the Hittite Old Kingdom. The toponym Kizzuwatna is possibly a Luwian adaptation of Hittite *kez-udne 'country on this side (of the mountains)', while the name Isputahsu is definitely Hittite and not Luwian (Yakubovich 2010, pp. 273–4). Hurrian culture became more prominent in Kizzuwatna once it entered the sphere of influence of the Hurrian kingdom of Mitanni.