Keratin 7

KRT7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XIF
Identifiers
Aliases	KRT7, CK7, K2C7, K7, SCL, keratin 7
External IDs	OMIM: 148059 MGI: 96704 HomoloGene: 4058 GeneCards: KRT7
Gene ontology Molecular function • protein binding • structural molecule activity Cellular component • cytoplasm • keratin filament • extracellular exosome • intermediate filament • nucleus • cytosol Biological process • viral process • keratinization • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3855	110310
Ensembl	ENSG00000135480	ENSMUSG00000023039
UniProt	P08729	Q9DCV7
RefSeq (mRNA)	NM_005556	NM_033073
RefSeq (protein)	NP_005547	NP_149064.1 NP_149064
Location (UCSC)	Chr 12: 52.23 – 52.25 Mb	Chr 15: 101.41 – 101.43 Mb
PubMed search

4XIF

3855

110310

ENSG00000135480

ENSMUSG00000023039

P08729

Q9DCV7

NM_005556

NM_033073

NP_005547

NP_149064.1
NP_149064

Keratin, type II cytoskeletal 7 also known as cytokeratin-7 (CK-7) or keratin-7 (K7) or sarcolectin (SCL) is a protein that in humans is encoded by the KRT7 gene. Keratin 7 is a type II keratin. It is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels.

Keratin-7 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described.

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