Keratin 18

KRT18
Identifiers
Aliases	KRT18, CK-18, CYK18, K18, keratin 18
External IDs	OMIM: 148070 MGI: 96692 HomoloGene: 55448 GeneCards: KRT18
Gene ontology Molecular function • scaffold protein binding • structural molecule activity • protein binding • cadherin binding involved in cell-cell adhesion • RNA binding Cellular component • cytoplasm • centriolar satellite • keratin filament • microtubule organizing center • nucleolus • perinuclear region of cytoplasm • extracellular exosome • intermediate filament • cell periphery • nucleus • cell-cell adherens junction • cytosol Biological process • Golgi to plasma membrane CFTR protein transport • extrinsic apoptotic signaling pathway • anatomical structure morphogenesis • negative regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • intermediate filament cytoskeleton organization • cell cycle • viral process • hepatocyte apoptotic process • cell-cell adhesion • keratinization • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3875	16668
Ensembl	ENSG00000111057	ENSMUSG00000023043
UniProt	P05783	P05784
RefSeq (mRNA)	NM_199187 NM_000224	NM_010664
RefSeq (protein)	NP_000215 NP_954657	NP_034794.2 NP_034794
Location (UCSC)	Chr 12: 52.95 – 52.95 Mb	Chr 15: 102.03 – 102.03 Mb
PubMed search

3875

16668

ENSG00000111057

ENSMUSG00000023043

P05783

P05784

NM_199187
NM_000224

NM_010664

NP_000215
NP_954657

NP_034794.2
NP_034794

Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.

Keratin 18 is often used together with keratin 8 and keratin 19 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.

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Wikipedia