Keratin 19

KRT19
Identifiers
Aliases	KRT19, CK19, K19, K1CS, keratin 19
External IDs	OMIM: 148020 MGI: 96693 HomoloGene: 1713 GeneCards: KRT19
Gene ontology Molecular function • protein complex binding • structural constituent of muscle • structural constituent of cytoskeleton • protein binding • structural molecule activity Cellular component • terminal web • plasma membrane • sarcolemma • costamere • dystrophin-associated glycoprotein complex • Z disc • extracellular exosome • intermediate filament • cell periphery • cytosol • apicolateral plasma membrane Biological process • Notch signaling pathway • viral process • sarcomere organization • cell differentiation involved in embryonic placenta development • response to estrogen • keratinization • cornification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3880	16669
Ensembl	ENSG00000171345	ENSMUSG00000020911
UniProt	P08727	P19001
RefSeq (mRNA)	NM_002276	NM_008471 NM_001313963
RefSeq (protein)	NP_002267	NP_001300892 NP_032497
Location (UCSC)	Chr 17: 41.52 – 41.53 Mb	Chr 11: 100.14 – 100.15 Mb
PubMed search

3880

16669

ENSG00000171345

ENSMUSG00000020911

P08727

P19001

NM_002276

NM_008471
NM_001313963

NP_002267

NP_001300892
NP_032497

Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. Keratin 19 is a type I keratin.

Keratin 19 is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins.

Keratin 19 is a type I keratin. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically found in the periderm, the transiently superficial layer that envelops the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.

...
Wikipedia