Keratin 10

KRT10
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4F1Z, 3ASW, 4ZRY
Identifiers
Aliases	KRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDs	OMIM: 148080 GeneCards: KRT10
Gene location (Human) Chr. Chromosome 17 (human) Band No data available Start 40,818,117 bp End 40,822,595 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • structural molecule activity • structural constituent of epidermis Cellular component • cytoplasm • extracellular exosome • intermediate filament • membrane • nucleus • extracellular space • cytosol • cornified envelope Biological process • keratinocyte differentiation • keratinization • cornification • peptide cross-linking • skin epidermis development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3858	n/a
Ensembl	ENSG00000186395	n/a
UniProt	P13645	n/a
RefSeq (mRNA)	NM_000421	n/a
RefSeq (protein)	NP_000412	n/a
Location (UCSC)	Chr 17: 40.82 – 40.82 Mb	n/a
PubMed search		n/a

4F1Z, 3ASW, 4ZRY

3858

n/a

ENSG00000186395

n/a

P13645

n/a

NM_000421

n/a

NP_000412

n/a

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 (CK-10) or keratin-10 (K10) is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.

Keratin-10 is a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.

Keratin 10 has been shown to interact with AKT1.

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