AKT1

AKT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN, 4EKK, 4EKL, 4GV1, 5KCV
Identifiers
Aliases	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, AKT serine/threonine kinase 1
External IDs	MGI: 87986 HomoloGene: 3785 GeneCards: AKT1
Gene ontology Molecular function • GTPase activating protein binding • kinase activity • nitric-oxide synthase regulator activity • ATP binding • protein kinase activity • protein phosphatase 2A binding • enzyme binding • phosphatidylinositol-3,4,5-trisphosphate binding • transferase activity • 14-3-3 protein binding • protein binding • protein serine/threonine/tyrosine kinase activity • protein kinase binding • protein kinase C binding • nucleotide binding • phosphatidylinositol-3,4-bisphosphate binding • identical protein binding • protein serine/threonine kinase activity Cellular component • cytoplasm • cytosol • membrane • cell-cell junction • mitochondrion • nucleus • ciliary basal body • microtubule cytoskeleton • plasma membrane • spindle • nucleoplasm • protein complex • vesicle • postsynapse Biological process • germ cell development • positive regulation of glucose import • cellular response to nerve growth factor stimulus • positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle • positive regulation of protein phosphorylation • positive regulation of lipid biosynthetic process • regulation of neuron projection development • activation-induced cell death of T cells • response to heat • regulation of cell cycle checkpoint • response to organic substance • response to insulin-like growth factor stimulus • positive regulation of endodeoxyribonuclease activity • cellular response to DNA damage stimulus • regulation of protein localization • platelet activation • protein phosphorylation • cellular response to mechanical stimulus • negative regulation of plasma membrane long-chain fatty acid transport • negative regulation of fatty acid beta-oxidation • cellular protein modification process • cell projection organization • cellular response to granulocyte macrophage colony-stimulating factor stimulus • positive regulation of blood vessel endothelial cell migration • glucose metabolic process • glycogen metabolic process • regulation of glycogen biosynthetic process • glycogen cell differentiation involved in embryonic placenta development • cell proliferation • negative regulation of autophagy • cellular response to hypoxia • negative regulation of cell size • endocrine pancreas development • carbohydrate transport • negative regulation of proteolysis • insulin-like growth factor receptor signaling pathway • positive regulation of cellular protein metabolic process • positive regulation of glycogen biosynthetic process • glucose homeostasis • chemical synaptic transmission, postsynaptic • labyrinthine layer blood vessel development • response to oxidative stress • negative regulation of gene expression • positive regulation of peptidyl-serine phosphorylation • positive regulation of establishment of protein localization to plasma membrane • cellular response to prostaglandin E stimulus • positive regulation of cell growth • positive regulation of nitric-oxide synthase activity • maternal placenta development • regulation of myelination • protein ubiquitination • positive regulation of vasoconstriction • hyaluronan metabolic process • spinal cord development • cellular response to insulin stimulus • cellular response to decreased oxygen levels • protein autophosphorylation • inflammatory response • positive regulation of fat cell differentiation • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • negative regulation of neuron death • G-protein coupled receptor signaling pathway • cell differentiation • cellular response to peptide • negative regulation of protein kinase activity • phosphorylation • carbohydrate metabolic process • regulation of mRNA stability • negative regulation of release of cytochrome c from mitochondria • execution phase of apoptosis • cellular response to organic cyclic compound • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of apoptotic process • positive regulation of glucose metabolic process • nervous system development • response to fluid shear stress • maintenance of protein location in mitochondrion • protein catabolic process • negative regulation of protein kinase activity by protein phosphorylation • osteoblast differentiation • transport • response to UV-A • response to hormone • peptidyl-threonine phosphorylation • phosphatidylinositol-mediated signaling • lipopolysaccharide-mediated signaling pathway • positive regulation of protein localization to nucleus • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • intracellular signal transduction • regulation of cell migration • peripheral nervous system myelin maintenance • nitric oxide biosynthetic process • positive regulation of endothelial cell proliferation • translation • protein kinase B signaling • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • protein import into nucleus, translocation • T cell costimulation • regulation of nitric-oxide synthase activity • aging • mammary gland epithelial cell differentiation • cellular response to epidermal growth factor stimulus • multicellular organism development • negative regulation of JNK cascade • glycogen biosynthetic process • establishment of protein localization to mitochondrion • apoptotic mitochondrial changes • peptidyl-serine phosphorylation • positive regulation of sodium ion transport • response to growth hormone • positive regulation of apoptotic process • response to food • cellular response to vascular endothelial growth factor stimulus • striated muscle cell differentiation • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of fibroblast migration • regulation of translation • glucose transport • positive regulation of transcription from RNA polymerase II promoter • signal transduction • negative regulation of endopeptidase activity • apoptotic process • positive regulation of epidermal growth factor receptor signaling pathway • interleukin-18-mediated signaling pathway • insulin receptor signaling pathway • regulation of phosphatidylinositol 3-kinase signaling • positive regulation of smooth muscle cell proliferation • regulation of signal transduction by p53 class mediator • G1/S transition of mitotic cell cycle • negative regulation of macroautophagy • TOR signaling • anoikis • positive regulation of organ growth • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	207	11651
Ensembl	ENSG00000142208	ENSMUSG00000001729
UniProt	P31749	P31750
RefSeq (mRNA)	NM_001014431 NM_001014432 NM_005163	NM_001165894 NM_009652 NM_001331107
RefSeq (protein)	NP_001014431 NP_001014432 NP_005154	NP_001159366.1 NP_033782.1 NP_001159366 NP_001318036 NP_033782
Location (UCSC)	Chr 14: 104.77 – 104.8 Mb	Chr 12: 112.65 – 112.67 Mb
PubMed search

1H10, 1UNP, 1UNQ, 1UNR, 2UVM, 2UZR, 2UZS, 3CQU, 3CQW, 3MV5, 3MVH, 3O96, 3OCB, 3OW4, 3QKK, 3QKL, 3QKM, 4EJN, 4EKK, 4EKL, 4GV1, 5KCV

207

11651

ENSG00000142208

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