Kasama Domain (笠間藩 Kasama-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Hitachi Province (modern-day Ibaraki Prefecture), Japan. It was centered on Kasama Castle in what is now the city of Kasama, Ibaraki. It was ruled by a number of clans during its early history, before settling under the rule of a junior branch of the Makino clan from the middle of the Edo period onward.
Kasama Castle was originally the stronghold of the Kasama clan, who ruled the region since the Kamakura period. However, the Kasama were destroyed by Toyotomi Hideyoshi for supporting the Odawara Hōjō, and their lands were given to the Utsunomiya clan, and subsequently to Gamo Hideyuki in 1598. Following the Battle of Sekigahara, Matsudaira Yasushige was promoted to 30,000 koku from his previous holding of Kisai Domain and was given the newly created Kasama Doman in 1601. However, he was transferred on to Shinoyama Domain in Tamba Province a few years later in 1608. He was replaced at Kasama by Ogasawara Yoshitsugu, who was then relieved of the domain less than a year later due to financial improprieties.
Kasama was revived in 1612 for Matsudaira Yasunaga, the former castellan of Fushimi Castle. He held the domain until his promotion to Takasaki Domain in 1616 for services rendered during the Siege of Osaka. He was replaced by Nagai Naokatsu, one of Tokugawa Ieyasu’s oldest retainers, until 1622.