Kakegawa Domain (掛川藩 Kakegawa-han?) was a feudal domain under the Tokugawa shogunate of Edo period Japan. The domain was centered at Kakegawa Castle in Tōtōmi Province, in what is now the city of Kakegawa, Shizuoka.
During the Sengoku Period, Kakegawa was a fortified settlement of the Imagawa clan. Following the defeat of the Imagawa at the hands of Oda Nobunaga at the Battle of Okehazama, Kakegawa, along with the rest of Tōtōmi Province came under the control of Takeda Shingen. Imagawa loyalist Asahina Yasutomo surrendered Kakegawa to Takeda ally Tokugawa Ieyasu. After the death of Takeda Shingen, Ieyasu took control of all of Tōtōmi Province, and assigned Kakegawa to his retainer Ishikawa Ienari. However, after the Battle of Odawara, Ieyasu was forced to surrender his domains in the Tōkai region to Toyotomi Hideyoshi in exchange for the provinces of the Kantō region. Toyotomi retainer Yamauchi Kazutoyo was assigned Kakegawa, and considerably improved on the structure of the castle and its moat system.
After the Battle of Sekigahara, Tokugawa Ieyasu regained control over the Tōkai region, and Yamauchi Kazutoyo surrendered Kakegawa in exchange for Tosa Province in Shikoku.