KMO (gene)

KMO
Identifiers
Aliases	KMO, dJ317G22.1, kynurenine 3-monooxygenase (kynurenine 3-hydroxylase), kynurenine 3-monooxygenase
External IDs	MGI: 2138151 HomoloGene: 2729 GeneCards: KMO
Gene location (Human) Chr. Chromosome 1 (human) Band 1q43 Start 241,532,134 bp End 241,595,642 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 H3 Start 175,620,381 bp End 175,662,116 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • NAD(P)H oxidase activity • FAD binding • monooxygenase activity • oxidoreductase activity • kynurenine 3-monooxygenase activity • flavin adenine dinucleotide binding Cellular component • integral component of membrane • cytosol • membrane • mitochondrial outer membrane • mitochondrion • mitochondrial inner membrane • extracellular exosome Biological process • pyridine nucleotide biosynthetic process • NAD biosynthetic process • response to salt stress • secondary metabolite biosynthetic process • quinolinate biosynthetic process • NAD metabolic process • kynurenine metabolic process • tryptophan catabolic process • oxidation-reduction process • tryptophan catabolic process to kynurenine Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8564	98256
Ensembl	ENSG00000117009	ENSMUSG00000039783
UniProt	O15229	Q91WN4
RefSeq (mRNA)	NM_003679	NM_133809
RefSeq (protein)	NP_003670	NP_598570
Location (UCSC)	Chr 1: 241.53 – 241.6 Mb	Chr 1: 175.62 – 175.66 Mb
PubMed search

8564

98256

ENSG00000117009

ENSMUSG00000039783

O15229

Q91WN4

NM_003679

NM_133809

NP_003670

NP_598570

Kynurenine 3-monooxygenase is an enzyme that in humans is encoded by the KMO gene.

Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.[supplied by OMIM] This is the first step in the degradation of Kyneurinine to Quinolinic acid. This pathway is involved in the activation of cytokine mediated changes in behavior due to inflammatory stimuli such as infections.

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