KLK5

Available structures

Human UniProt search: PDBe RCSB

List of PDB id codes
2PSX, 2PSY

Identifiers

Aliases

KLK5, KLK-L2, KLKL2, SCTE, kallikrein related peptidase 5

External IDs

MGI: 1915918 HomoloGene: 75000 GeneCards: KLK5

Gene ontology
Molecular function	• protein binding • hydrolase activity • peptidase activity • serine-type peptidase activity • endopeptidase activity • serine-type endopeptidase activity
Cellular component	• epidermal lamellar body • extracellular region • extracellular space • cytosol
Biological process	• positive regulation of antibacterial peptide production • positive regulation of G-protein coupled receptor protein signaling pathway • proteolysis • epidermis development • cornification
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


25818


68668

Ensembl


ENSG00000167754


ENSMUSG00000074155

UniProt


Q9Y337


n/a

RefSeq (mRNA)


NM_001077491 NM_001077492 NM_012427


NM_026806

RefSeq (protein)


NP_001070959 NP_001070960 NP_036559


n/a

Location (UCSC)

Chr 19: 50.94 – 50.95 Mb

Chr 7: 43.84 – 43.85 Mb

PubMed search

n/a

NM_001077491
NM_001077492
NM_012427

NM_026806

NP_001070959
NP_001070960
NP_036559

n/a

Kallikrein-related peptidase 5 (KLK5), formerly known as stratum corneum tryptic enzyme (SCTE), is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. Alternative splicing results in multiple transcript variants encoding the same protein.

KLK5 has been suggested to regulate cell shedding (desquamation) in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. It is proposed that KLK5 regulates this process since it is able to self-activate in addition to activating KLK7 and KLK14.

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