KLK14

KLK14
Identifiers
Aliases	KLK14, KLK-L6, kallikrein related peptidase 14
External IDs	MGI: 2447564 HomoloGene: 69348 GeneCards: KLK14
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.41 Start 51,077,495 bp End 51,084,245 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 28.26 cM Start 43,690,418 bp End 43,695,536 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • peptidase activity • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cellular component • extracellular exosome • extracellular region • extracellular space Biological process • fertilization • epidermis morphogenesis • seminal clot liquefaction • positive regulation of G-protein coupled receptor protein signaling pathway • negative regulation of G-protein coupled receptor protein signaling pathway • proteolysis • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	43847	317653
Ensembl	ENSG00000129437	ENSMUSG00000044737
UniProt	Q9P0G3	Q8CGR5
RefSeq (mRNA)	NM_001311182 NM_022046	NM_174866
RefSeq (protein)	NP_001298111 NP_071329	NP_777355
Location (UCSC)	Chr 19: 51.08 – 51.08 Mb	Chr 19: 43.69 – 43.7 Mb
PubMed search

43847

317653

ENSG00000129437

ENSMUSG00000044737

Q9P0G3

Q8CGR5

NM_001311182
NM_022046

NM_174866

NP_001298111
NP_071329

NP_777355

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. An additional transcript variant has been described but its full length nature has not been determined.

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Wikipedia