KLF4

KLF4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WBS, 2WBU, 4M9E
Identifiers
Aliases	KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
External IDs	MGI: 1342287 HomoloGene: 3123 GeneCards: KLF4
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • beta-catenin binding • phosphatidylinositol 3-kinase regulator activity • core promoter binding • RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase binding • transcription factor binding • core promoter proximal region sequence-specific DNA binding • metal ion binding • regulatory region DNA binding • transcriptional activator activity, RNA polymerase II transcription factor binding • transcription factor activity, sequence-specific DNA binding transcription factor recruiting • protein binding • nucleic acid binding • transcription regulatory region DNA binding • transcription cofactor binding • double-stranded DNA binding • promoter-specific chromatin binding Cellular component • cytoplasm • nuclear euchromatin • nuclear transcription factor complex • transcription factor complex • nucleoplasm • nuclear chromatin • chromatin • nucleus Biological process • negative regulation of chemokine (C-X-C motif) ligand 2 production • epidermal cell differentiation • cellular response to retinoic acid • negative regulation of protein kinase B signaling • negative regulation of muscle hyperplasia • negative regulation of smooth muscle cell proliferation • positive regulation of cellular protein metabolic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of axon regeneration • cellular response to peptide • regulation of transcription, DNA-templated • positive regulation of hemoglobin biosynthetic process • response to retinoic acid • somatic stem cell population maintenance • cellular response to laminar fluid shear stress • regulation of transcription from RNA polymerase II promoter • cell differentiation • epidermis morphogenesis • positive regulation of nitric oxide biosynthetic process • cellular response to growth factor stimulus • cellular response to organic cyclic compound • post-embryonic hemopoiesis • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • response to organic substance • negative regulation of interleukin-8 biosynthetic process • negative regulation of gene expression • negative regulation of response to cytokine stimulus • positive regulation of protein metabolic process • transcription, DNA-templated • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of phosphatidylinositol 3-kinase signaling • stem cell population maintenance • positive regulation of transcription, DNA-templated • negative regulation of cell migration involved in sprouting angiogenesis • positive regulation of gene expression • negative regulation of cell migration • regulation of cell proliferation • post-embryonic camera-type eye development • regulation of phosphatidylinositol 3-kinase activity • positive regulation of telomerase activity • canonical Wnt signaling pathway • negative regulation of ERK1 and ERK2 cascade • regulation of cell differentiation • mesodermal cell fate determination • negative regulation of heterotypic cell-cell adhesion • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • cellular response to cycloheximide • negative regulation of inflammatory response • fat cell differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • cellular response to hydrogen peroxide • negative regulation of leukocyte adhesion to arterial endothelial cell • positive regulation of core promoter binding Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9314	16600
Ensembl	ENSG00000136826	ENSMUSG00000003032
UniProt	O43474	Q60793
RefSeq (mRNA)	NM_001314052 NM_004235	NM_010637
RefSeq (protein)	NP_001300981 NP_004226	NP_034767.2 NP_034767
Location (UCSC)	Chr 9: 107.48 – 107.49 Mb	Chr 4: 55.53 – 55.53 Mb
PubMed search

2WBS, 2WBU, 4M9E

9314

16600

ENSG00000136826

ENSMUSG00000003032

O43474

Q60793

NM_001314052
NM_004235

NM_010637

NP_001300981
NP_004226

NP_034767.2
NP_034767

Kruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a zinc-finger transcription factor, and it was first identified in 1996. KLF4 is a member of the KLF family of transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including Colorectal cancer. It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

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Wikipedia