KLF15

KLF15
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ENT
Identifiers
Aliases	KLF15, KKLF, Kruppel-like factor 15, Kruppel like factor 15
External IDs	MGI: 1929988 HomoloGene: 8553 GeneCards: KLF15
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • metal ion binding • nucleic acid binding Cellular component • nucleus Biological process • regulation of gene expression • glomerular visceral epithelial cell differentiation • positive regulation of transcription, DNA-templated • cellular response to peptide • negative regulation of peptidyl-lysine acetylation • glial cell differentiation • cardiac muscle hypertrophy in response to stress • regulation of transcription, DNA-templated • glucose transport • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	28999	66277
Ensembl	ENSG00000163884	ENSMUSG00000030087
UniProt	Q9UIH9	Q9EPW2
RefSeq (mRNA)	NM_014079	NM_023184
RefSeq (protein)	NP_054798	NP_075673
Location (UCSC)	Chr 3: 126.34 – 126.36 Mb	Chr 6: 90.46 – 90.48 Mb
PubMed search

2ENT

28999

66277

ENSG00000163884

ENSMUSG00000030087

Q9UIH9

Q9EPW2

NM_014079

NM_023184

NP_054798

NP_075673

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.

Activated glucocorticoid receptor upregulates the expression of KLF15.

KLF15 is increased by fasting and decreased by feeding and insulin via PI3K signalling. KLF15 was increased by glucocorticoid signalling and was also increased by inhibition of PI3K. Insulin and its counteracting hormones regulate the hepatic expression of KLF15. Forced expression of KLF15 in cultured hepatocytes increased both the expression and the promoter activity of the gene for phosphoenolpyruvate carboxykinase (PEPCK).

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