KLF13

Identifiers

KLF13, BTEB3, FKLF2, NSLP1, RFLAT-1, RFLAT1, Kruppel-like factor 13, Kruppel like factor 13

External IDs

MGI: 1354948 HomoloGene: 32288 GeneCards: KLF13

Gene ontology
Molecular function	• RNA polymerase II core promoter proximal region sequence-specific DNA binding • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • metal ion binding • nucleic acid binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding
Cellular component	• nucleus
Biological process	• regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • negative regulation of erythrocyte differentiation • transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


51621


50794

Ensembl


n/a


ENSMUSG00000052040

UniProt


Q9Y2Y9


Q9JJZ6

RefSeq (mRNA)


NM_001302461 NM_015995


NM_021366

RefSeq (protein)


NP_001289390 NP_057079


NP_067341.2 NP_067341

Location (UCSC)

Chr 15: 31.33 – 31.44 Mb

Chr 7: 63.89 – 63.94 Mb

PubMed search

n/a

NM_001302461
NM_015995

NM_021366

NP_001289390
NP_057079

NP_067341.2
NP_067341

Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.

There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.Ghrelin levels also positively correlated with methylation levels of cg07814318. Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.

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