KCNH1

KCNH1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5J7E
Identifiers
Aliases	KCNH1, EAG, EAG1, Kv10.1, h-eag, TMBTS, ZLS1, hEAG1, potassium voltage-gated channel subfamily H member 1
External IDs	MGI: 1341721 HomoloGene: 68242 GeneCards: KCNH1
Targeted by Drug
astemizole, clofilium, dofetilide, E4031, haloperidol, imipramine, quinidine, terfenadine
Gene ontology Molecular function • phosphorelay sensor kinase activity • protein kinase binding • 14-3-3 protein binding • identical protein binding • voltage-gated potassium channel activity • calmodulin binding • protein heterodimerization activity • cyclic nucleotide binding • ion channel activity • ion channel binding • potassium channel activity • voltage-gated ion channel activity • protein binding • delayed rectifier potassium channel activity • lipid binding • phosphatidylinositol bisphosphate binding Cellular component • synapse • integral component of membrane • nucleus • axon • nuclear inner membrane • presynaptic membrane • membrane • cell surface • early endosome membrane • neuronal cell body • dendrite • perinuclear region of cytoplasm • plasma membrane • endosome • axolemma • voltage-gated potassium channel complex • integral component of plasma membrane • postsynaptic density • cell junction • potassium channel complex • cell projection • perikaryon • intracellular membrane-bounded organelle • postsynaptic membrane Biological process • startle response • transmembrane transport • regulation of cell proliferation • potassium ion transport • signal transduction by protein phosphorylation • phosphorelay signal transduction system • regulation of ion transmembrane transport • ion transport • transport • potassium ion transmembrane transport • ion transmembrane transport • myoblast fusion • regulation of membrane potential • phosphatidylinositol-mediated signaling • cellular response to calcium ion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3756	16510
Ensembl	ENSG00000143473	ENSMUSG00000058248
UniProt	O95259	Q60603
RefSeq (mRNA)	NM_002238 NM_172362	NM_001038607 NM_010600
RefSeq (protein)	NP_002229 NP_758872	NP_034730.1 NP_001033696 NP_034730
Location (UCSC)	Chr 1: 210.68 – 211.13 Mb	Chr 1: 192.19 – 192.51 Mb
PubMed search

5J7E

3756

16510

ENSG00000143473

ENSMUSG00000058248

O95259

Q60603

NM_002238
NM_172362

NM_001038607
NM_010600

NP_002229
NP_758872

NP_034730.1
NP_001033696
NP_034730

Potassium voltage-gated channel subfamily H member 1 is a protein that in humans is encoded by the KCNH1 gene.

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

...
Wikipedia