In the main event World Heavyweight Champion Rey Mysterio defeated John "Bradshaw" Layfield following a Frog splash. One of the predominant matches on the undercard was Booker T versus Bobby Lashley in the finals of the 2006 King of the Ring tournament, which Booker won after interference from Finlay. Another primary match was Kurt Angle versus Mark Henry, which Henry won after Angle was counted out. The theme song "This Fire Burns" was temporarily used as the theme song for Randy Orton but later became the official theme song for CM Punk until 2011.

On the May 5 episode of SmackDown!, after Rey Mysterio expressed his feelings about being World Heavyweight Champion, John "Bradshaw" Layfield came out and declared himself the number-one contender. JBL immediately began degrading Mysterio because of his Mexican heritage, saying he was an illegal immigrant and that Mysterio doesn’t deserve to be champion. Mysterio reacted by saying that he'd fight anyone at any time. In turn, JBL announced that Mysterio would face off against Mark Henry later that night. During the match, Mysterio tried to use his quickness to avoid Henry, but was easily countered by Henry's power. Mysterio was able to hit a 619 and a Seated senton, but was defeated when Henry hit the World's Strongest Slam for the pin. The next week on SmackDown!, JBL announced that Mysterio would take on The Great Khali later that night. During the match, Mysterio attempted a springboard dropkick, but it had no effect. Khali then picked up Mysterio and hit a Two-handed chokeslam for the win. On the May 19 episode of SmackDown!, JBL said that Mysterio didn't look so well due to the beatings he endured in past weeks and that he probably didn't even know what day it was. Mysterio answered and told him the day, May 19. Kane, who in recent weeks attacked anyone who said May 19, came out and faced off against Mysterio. Kane dominated most of the match, hitting a variety of power moves. Kane then began to hear voices in his head saying May 19, which caused him to go into a psychotic trance. JBL told him to finish the job, but mistakenly said May 19, causing Kane to attack him. As a result, the match ended in a no-contest.

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