Joseph Sambrook
| Joseph Sambrook | |
|---|---|
| Born |
1 March 1939 Liverpool, England |
| Residence | Melbourne, Australia |
| Fields | Molecular biology |
| Institutions | MRC Laboratory of Molecular Biology, Salk Institute for Biological Studies, Cold Spring Harbor Laboratory, University of Texas Southwestern Medical Center, Peter MacCallum Cancer Centre |
| Alma mater | Australian National University |
| Known for | Laboratory manual Molecular Cloning, work on oncoviruses |
| Notable awards | Victorian Government Leadership and Innovation Award, Elected Fellow of the Australian Academy of Science and the Royal Society |
Joseph Frank Sambrook (born 1 March 1939 in Liverpool, England) is a British molecular biologist known for his studies of DNA oncoviruses and the molecular biology of normal and cancerous cells. He resides in Melbourne, Australia with his wife and daughter.
Sambrook was educated at the University of Liverpool (BSc (hons) 1962) and obtained his PhD at the Australian National University in 1966. He did postdoctoral research at the MRC Laboratory of Molecular Biology (1966–67) and the Salk Institute for Biological Studies (1967–69). In 1969 he was hired by James D. Watson to work at the Cold Spring Harbor Laboratory in New York. Watson has been reported to say this was the best hiring decision he ever made. Joe was responsible for creating a combative creative environment at CSHL that fomented discovery. Subsequently he worked at the University of Texas Southwestern Medical Center (Dallas).
Sambrook is best known for his studies on DNA tumor viruses and the molecular biology of normal and neoplastic cells. His Tumour Virus Group at Cold Spring Harbor identified and mapped all of the major genes of adenoviruses and SV40, determined their transcriptional control in infected and transformed cells, and elucidated the mechanism of integration of these viruses into the genome of the host cell. He has also made important contributions to the understanding of intracellular traffic and protein folding and is an influential leader in the field of the molecular genetics of human cancer.
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