Janikhel (Pashto: جاني خېل ولسوالۍ, Persian: ولسوالی جانیخیل) is a district in Paktika Province, in eastern Afghanistan. It was created in 2004 out of part of Zarghun Shahr District.
Like in the rest of Afghanistan, no exact population numbers are available. The Afghan Ministry of Rural Rehabilitation & Development (MRRD) along with UNHCR and Central Statistics Office (CSO) of Afghanistan estimated the population of the district to be around 40,340 (CSO 2004). According to the same sources, Pashtuns make up 100% of the total population.