James White (June 16, 1749 – October, 1809) was an American physician, lawyer, and politician. He was an early settler at Nashville, Tennessee and in Louisiana. He was a delegate for North Carolina in the Continental Congress and a non-voting member of the U.S. House for the Southwest Territory. In historical writings, he is usually referred to as "Dr. James White" to distinguish him from General James White, the founder of Knoxville, Tennessee.
White was born into a prosperous mercantile family in Philadelphia, Pennsylvania. His early education was at the College of St. Omer, a Jesuit school in modern-day France (then part of the Spanish Netherlands). When he returned he entered the University of Pennsylvania and studied medicine and law. After graduating he moved to the Province of North Carolina.
In 1785, White was elected to the North Carolina House of Representatives. In 1786, North Carolina sent him as a delegate to the Continental Congress where he served until 1788. Late in 1786, Congress named him Superintendent of Indian Affairs for the southern department. After that he was frequently absent from Congress, traveling the Carolina and Georgia frontiers negotiating with the Indian tribes. After his congressional service he moved to the frontier, buying land and settling in what became Nashville, Tennessee.