Jacob Spon (or Jacques; in English dictionaries given as James) (Lyon 1647 – Vevey, Switzerland, 25 December 1685), a French doctor and archaeologist, was a pioneer in the exploration of the monuments of Greece and a scholar of international reputation in the developing "Republic of Letters".
His father was Charles Spon, a doctor and Hellenist, of a wealthy and cultured Calvinist banking family from Ulm that had been established since 1551 at Lyon, where they were members of the bourgeois élite. Following medical studies at Strasburg, the younger Spon first met the son of a friend of his father, Charles Patin, who introduced him to antiquarian interests and the study of numismatics, then as now a window into the world of Classical Antiquity. In Paris, Jacob Spon lodged with Patin's father, Guy Patin. At Montpellier he received his doctorate in medicine (1668) and subsequently practiced in Lyon to a wealthy clientele. There his first publication appeared, a Recherche des antiquités et curiosités de la ville de Lyon and he entered into correspondence with a wider circle of savants: the abbé Claude Nicaise at Dijon, du Cange at Paris, the erudite circles that gravitated to le Grand Dauphin and the duc d'Aumont. Among his correspondents were the courtier-theologian Jacques-Bénigne Bossuet, the philosopher Pierre Bayle, Pierre Carcavy, the Jesuit scholar François d'Aix de la Chaise, confessor to the King, and François Charpentier. He met Jean Mabillon when Mabillon passed through Lyon in 1682.