Išḫi-Addu or Ishi-Addu was king of Qatna in the first half of the 18th century BC. He is known for his correspondences with Shamshi-Adad I of Assyria who was his closest ally. Qatna was at its height during Išḫi-Addu's reign, which was, however, plagued with revolts in the southern parts of the kingdom and with constant war with Yamhad, Qatna's northern neighbour.
Išḫi-Addu is mainly known from his correspondences with Mari for a period of six years between c. 1783–1778 BC. When his reign began is uncertain; he succeeded Amut-piʾel I, who is most probably his father. Qatna was at its apex during the reign of Išḫi-Addu; he was the overlord of Hazor, and the many kingdoms of Amurru which controlled the central Levantine coast between Byblos and Ugarit acknowledged his authority. Išḫi-Addu was a close ally of Shamshi-Adad I of Assyria who conquered Mari and installed his son Yasmah-Adad on its throne. The alliance between Qatna and Assyria was concluded shortly after Yasmah-Adad installation; it was cemented by the c. 1782 BC marriage of Dam-Ḫuraṣi, Išḫi-Addu's daughter, to Yasmah-Adad. The dowry of Qatna's princess was huge and Išhi-Addu demanded his vassals to contribute; a tablet discovered in Hazor contains orders from Qatna for the providing of large quantities of commodities such as textiles, objects made of precious metals and weapons.
Since early in their history, Qatna and Yamhad shared a hostile relation; the situation worsened during Išḫi-Addu's reign and evolved into border warfare. Qatna occupied the city of Parga in the region of Hamath for a while before Sumu-Epuh of Yamhad retook it. In the south, Išḫi-Addu faced a general rebellion; after petitions by Qatna, Shamshi-Adad sent an army to help Išḫi-Addu dealing with the rebellion. Shamshi-Adad planned to send an army of 20,000 soldiers and for his son Yasmah-Adad to lead them leadership, but these plans could not be realized. Instead, a much more modest army was sent under command from generals who were put in the service of Išḫi-Addu in c. 1781 BC. The Assyrian troops avoided engaging Yamhad and did not participate in its war with Qatna while Išḫi-Addu took up residence in Qadeš to oversee the suppression of the rebellion, which apparently was supported by Yamhad. A fortress near lake Qattinah was named after the king "Dur-Išḫi-Addu".