Iodotyrosine deiodinase
| Iodotyrosine deiodinase | |||||||||
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| EC number | 1.21.1.1 | ||||||||
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| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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| PMC | articles |
| PubMed | articles |
| NCBI | proteins |
| IYD | |||||||||||||||||
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| Identifiers | |||||||||||||||||
| Aliases | IYD, iodotyrosine deiodinase, C6orf71, DEHAL1, TDH4, dJ422F24.1, IYD-1 | ||||||||||||||||
| External IDs | MGI: 1917587 HomoloGene: 12352 GeneCards: IYD | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 6: 150.37 – 150.41 Mb | Chr 10: 3.54 – 3.55 Mb | |||||||||||||||
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NM_001164694
NM_001164695
NM_203395
NM_001318495
NP_001158166
NP_001158167
NP_001305424
NP_981932
Iodotyrosine deiodinase, also known as iodotyrosine dehalogenase 1, is a type of deiodinase enzyme that scavenges iodide by removing it from iodinated tyrosine residues in the thyroid gland. These iodinated tyrosines are produced during thyroid hormone biosynthesis. The iodide that is scavenged by iodotyrosine deiodinase is necessary to again synthesize the thyroid hormones. After synthesis, the thyroid hormones circulate through the body to regulate metabolic rate, protein expression, and body temperature. Iodotyrosine deiodinase is thus necessary to keep levels of both iodide and thyroid hormones in balance.
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Wikipedia