Involucrin

IVL
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1EU0
Identifiers
Aliases	IVL, involucrin
External IDs	HomoloGene: 136793 GeneCards: IVL
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 152,908,545 bp End 152,911,886 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding, bridging • protein binding • structural molecule activity Cellular component • cytoplasm • extracellular exosome • cornified envelope • centrosome • cytosol • nuclear body Biological process • response to UV-B • peptide cross-linking • keratinization • isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine • keratinocyte differentiation • cornification Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3713	n/a
Ensembl	ENSG00000163207	n/a
UniProt	P07476	n/a
RefSeq (mRNA)	NM_005547	n/a
RefSeq (protein)	NP_005538	n/a
Location (UCSC)	Chr 1: 152.91 – 152.91 Mb	n/a
PubMed search		n/a

Involucrin of squamous epithelia N-terminus
Identifiers
Symbol	Involucrin_N
Pfam	PF10583
InterPro	IPR019571
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Involucrin repeat
Identifiers
Symbol	Involucrin
Pfam	PF00904
InterPro	IPR000354
SCOP	1eu0
SUPERFAMILY	1eu0
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Involucrin repeat
Identifiers
Symbol	Involucrin2
Pfam	PF06994
InterPro	IPR009733
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1EU0

3713

n/a

ENSG00000163207

n/a

P07476

n/a

NM_005547

n/a

NP_005538

n/a

Involucrin is a protein component of human skin and in humans is encoded by the IVL gene. In binding the protein loricrin, involucrin contributes to the formation of a cell envelope that protects corneocytes in the skin.

This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

Involucrin is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. It first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane functioning as a glutamyl donor during assembly of the cornified envelope.

...
Wikipedia