Interleukin 5

IL5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VA2, 1HUL, 3QT2
Identifiers
Aliases	IL5, EDF, IL-5, TRF, interleukin 5
External IDs	OMIM: 147850 MGI: 96557 HomoloGene: 679 GeneCards: IL5
Gene ontology Molecular function • interleukin-5 receptor binding • protein binding • growth factor activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • cytokine activity Cellular component • extracellular region • intracellular • extracellular space Biological process • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of podosome assembly • MAPK cascade • positive regulation of transcription, DNA-templated • immune response • positive regulation of cell proliferation • positive regulation of eosinophil differentiation • positive regulation of peptidyl-tyrosine phosphorylation • inflammatory response • positive regulation of JAK-STAT cascade • positive regulation of GTPase activity • peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • positive regulation of B cell proliferation • positive regulation of immunoglobulin secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3567	16191
Ensembl	ENSG00000113525	ENSMUSG00000036117
UniProt	P05113	P04401
RefSeq (mRNA)	NM_000879	NM_010558
RefSeq (protein)	NP_000870	NP_034688.1 NP_034688
Location (UCSC)	Chr 5: 132.54 – 132.56 Mb	Chr 11: 53.72 – 53.73 Mb
PubMed search

3VA2, 1HUL, 3QT2

3567

16191

ENSG00000113525

ENSMUSG00000036117

P05113

P04401

NM_000879

NM_010558

NP_000870

NP_034688.1
NP_034688

Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells.

Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion. It is also a key mediator in eosinophil activation.

IL-5 is a 115-amino acid (in human, 133 in the mouse) -long TH2 cytokine that is part of the hematopoietic family. Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer.

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