Interleukin 3

IL3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1JLI
Identifiers
Aliases	IL3, interleukin 3, IL-3, MCGF, MULTI-CSF
External IDs	OMIM: 147740 HomoloGene: 47938 GeneCards: IL3
Gene ontology Molecular function • growth factor activity • interleukin-3 receptor binding • cytokine activity • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity • interleukin-1 receptor binding Cellular component • extracellular region • intracellular • extracellular space Biological process • positive regulation of DNA replication • MAPK cascade • embryonic hemopoiesis • cell-cell signaling • nervous system development • positive regulation of tyrosine phosphorylation of Stat5 protein • positive regulation of peptidyl-tyrosine phosphorylation • cytokine-mediated signaling pathway • immune response • positive regulation of cell proliferation • positive regulation of GTPase activity • peptidyl-tyrosine phosphorylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3562	n/a
Ensembl	ENSG00000164399	n/a
UniProt	P08700	n/a
RefSeq (mRNA)	NM_000588	n/a
RefSeq (protein)	NP_000579	n/a
Location (UCSC)	Chr 5: 132.06 – 132.06 Mb	n/a
PubMed search		n/a

1JLI

3562

n/a

ENSG00000164399

n/a

P08700

n/a

NM_000588

n/a

NP_000579

n/a

Interleukin 3 (IL-3) is a protein that in humans is encoded by the IL3 gene.

Interleukin 3 is an interleukin, a type of biological signal (cytokine) that can improve the body's natural response to disease as part of the immune system. It acts by binding to the interleukin-3 receptor.

Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells. In addition, IL-3 stimulates proliferation of all cells in the myeloid lineage (granulocytes, monocytes, and dendritic cells), in conjunction with other cytokines, e.g., Erythropoietin (EPO), Granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6. It is secreted by basophils and activated T cells to support growth and differentiation of T cells from the bone marrow in an immune response. Activated T cells can either induce their own proliferation and differentiation ( signalling), or that of other T cells (paracrine signalling) - both involve IL-2 binding to the IL-2 receptor on T cells (upregulated upon cell activation, under the induction of macrophage-secreted IL-1). The human IL-3 gene encodes a protein 152 amino acids long, and the naturally occurring IL-3 is glycosylated. The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF.

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