Granulocyte macrophage colony-stimulating factor

CSF2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1
Identifiers
Aliases	CSF2, GMCSF, colony stimulating factor 2
External IDs	MGI: 1339752 HomoloGene: 600 GeneCards: CSF2
Gene ontology Molecular function • growth factor activity • cytokine activity • granulocyte macrophage colony-stimulating factor receptor binding • protein binding • protein tyrosine kinase activity • Ras guanyl-nucleotide exchange factor activity Cellular component • extracellular region • extracellular space • intracellular membrane-bounded organelle Biological process • negative regulation of cytolysis • positive regulation of tyrosine phosphorylation of Stat5 protein • positive regulation of macrophage derived foam cell differentiation • regulation of cell proliferation • MAPK cascade • positive regulation of podosome assembly • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of cell proliferation • positive regulation of DNA replication • positive regulation of interleukin-23 production • positive regulation of gene expression • embryonic placenta development • epithelial fluid transport • regulation of gene expression • dendritic cell differentiation • myeloid dendritic cell differentiation • macrophage activation • cellular response to lipopolysaccharide • immune response • positive regulation of GTPase activity • monocyte differentiation • response to fluid shear stress • response to silicon dioxide • neutrophil differentiation • peptidyl-tyrosine phosphorylation • regulation of circadian sleep/wake cycle, sleep • histamine secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1437	12981
Ensembl	ENSG00000164400	ENSMUSG00000018916
UniProt	P04141	P01587
RefSeq (mRNA)	NM_000758	NM_009969
RefSeq (protein)	NP_000749	NP_034099.2 NP_034099
Location (UCSC)	Chr 5: 132.07 – 132.08 Mb	Chr 11: 54.25 – 54.25 Mb
PubMed search

Granulocyte-macrophage colony-stimulating factor
three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM_CSF)
Identifiers
Symbol	GM_CSF
Pfam	PF01109
Pfam clan	CL0053
InterPro	IPR000773
PROSITE	PDOC00584
SCOP	2gmf
SUPERFAMILY	2gmf
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Granulocyte macrophage colony-stimulating factor

Clinical data
ATC code	L03AA09 (WHO)
Identifiers
IUPAC name Human granulocyte macrophage colony stimulating factor
CAS Number	83869-56-1 Y
DrugBank	DB00020 N
ChemSpider	none
Chemical and physical data
Formula	C639H1006N168O196S8
Molar mass	14434.5 g/mol
NY (what is this?)

1CSG, 2GMF, 4NKQ, 5C7X, 5D70, 5D71, 5D72, 4RS1

1437

12981

ENSG00000164400

ENSMUSG00000018916

P04141

P01587

NM_000758

NM_009969

NP_000749

NP_034099.2
NP_034099

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.