Interleukin 25

IL25
Identifiers
Aliases	IL25, IL17E, IL-25, interleukin 25
External IDs	MGI: 2155888 HomoloGene: 15429 GeneCards: IL25
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 23,372,809 bp End 23,376,403 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C2 Start 54,932,695 bp End 54,935,837 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • interleukin-17E receptor binding • cytokine activity Cellular component • extracellular region • extracellular space Biological process • response to fungus • interleukin-13 production • response to nematode • inflammatory response to antigenic stimulus • eosinophil differentiation • positive regulation of transcription from RNA polymerase II promoter • interleukin-5 production • inflammatory response • cellular response to interleukin-17 • regulation of receptor activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	64806	140806
Ensembl	ENSG00000166090	ENSMUSG00000040770
UniProt	Q9H293	Q8VHH8
RefSeq (mRNA)	NM_172314 NM_022789	NM_080729
RefSeq (protein)	NP_073626 NP_758525	NP_542767
Location (UCSC)	Chr 14: 23.37 – 23.38 Mb	Chr 14: 54.93 – 54.94 Mb
PubMed search

64806

140806

ENSG00000166090

ENSMUSG00000040770

Q9H293

Q8VHH8

NM_172314
NM_022789

NM_080729

NP_073626
NP_758525

NP_542767

Interleukin-25 (IL-25) – also known as interleukin-17E (IL-17E) – is a protein that in humans is encoded by the IL25 gene.

IL-25 is a cytokine that shares the sequence similarity with IL-17. This cytokine can induce NF-κB activation, and stimulate the production of IL-8. Both this cytokine and IL17B are ligands for the cytokine receptor IL17RB. Studies of the similar gene in mice suggested that this cytokine may be a proinflammatory cytokine favoring Th2-type immune response. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

...
Wikipedia