IL17RB

IL17RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3VBC
Identifiers
Aliases	IL17RB, CRL4, EVI27, IL17BR, IL17RH1, interleukin 17 receptor B
External IDs	MGI: 1355292 HomoloGene: 10287 GeneCards: IL17RB
Gene ontology Molecular function • cytokine receptor activity • interleukin-17 receptor activity Cellular component • cytoplasm • integral component of membrane • extracellular region • cell surface • integral component of plasma membrane • membrane • plasma membrane Biological process • positive regulation of interleukin-5 secretion • defense response • positive regulation of inflammatory response • positive regulation of interleukin-13 secretion • regulation of cell growth • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55540	50905
Ensembl	ENSG00000056736	ENSMUSG00000015966
UniProt	Q9NRM6	Q9JIP3
RefSeq (mRNA)	NM_018725 NM_172234	NM_019583
RefSeq (protein)	NP_061195	NP_062529.2 NP_062529
Location (UCSC)	Chr 3: 53.85 – 53.87 Mb	Chr 14: 30 – 30.01 Mb
PubMed search

3VBC

55540

50905

ENSG00000056736

ENSMUSG00000015966

Q9NRM6

Q9JIP3

NM_018725
NM_172234

NM_019583

NP_061195

NP_062529.2
NP_062529

Interleukin-17 receptor B is a protein that in humans is encoded by the IL17RB gene.

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17(A) or IL17C. This receptor has been shown to mediate the activation of NF-κB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.

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Wikipedia