Interleukin 1 beta

IL1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP
Identifiers
Aliases	IL1B, IL-1, IL1-BETA, IL1F2, interleukin 1 beta
External IDs	OMIM: 147720 MGI: 96543 HomoloGene: 481 GeneCards: IL1B
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.1 Start 112,829,751 bp End 112,836,903 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band n/a Start 129,364,570 bp End 129,371,139 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein domain specific binding • interleukin-1 receptor binding • cytokine activity Cellular component • cytoplasm • cytosol • extracellular region • lysosome • extracellular exosome • secretory granule • vesicle • extracellular space Biological process • positive regulation of protein phosphorylation • smooth muscle adaptation • positive regulation of calcidiol 1-monooxygenase activity • negative regulation of insulin receptor signaling pathway • cellular response to mechanical stimulus • cellular response to drug • positive regulation of histone phosphorylation • positive regulation of interleukin-8 production • positive regulation of mitotic nuclear division • response to carbohydrate • embryo implantation • regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of cell proliferation • apoptotic process • cellular response to organic substance • positive regulation of phagocytosis • positive regulation of interleukin-6 secretion • regulation of insulin secretion • neutrophil chemotaxis • positive regulation of interleukin-2 biosynthetic process • positive regulation of transcription, DNA-templated • positive regulation of protein export from nucleus • positive regulation of prostaglandin secretion • positive regulation of myosin light chain kinase activity • negative regulation of MAP kinase activity • positive regulation of T cell proliferation • positive regulation of interleukin-6 production • inflammatory response • negative regulation of lipid metabolic process • sequestering of triglyceride • hyaluronan biosynthetic process • positive regulation of heterotypic cell-cell adhesion • positive regulation of lipid catabolic process • cellular response to organic cyclic compound • positive regulation of fever generation • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of interleukin-6 biosynthetic process • positive regulation of angiogenesis • response to lipopolysaccharide • activation of MAPK activity • positive regulation of NF-kappaB transcription factor activity • positive regulation of granulocyte macrophage colony-stimulating factor production • immune response • ectopic germ cell programmed cell death • leukocyte migration • lipopolysaccharide-mediated signaling pathway • positive regulation of vascular endothelial growth factor receptor signaling pathway • positive regulation of cell adhesion molecule production • response to ATP • monocyte aggregation • protein kinase B signaling • positive regulation of chemokine biosynthetic process • positive regulation of nitric oxide biosynthetic process • cell-cell signaling • positive regulation of monocyte chemotactic protein-1 production • regulation of nitric-oxide synthase activity • positive regulation of membrane protein ectodomain proteolysis • positive regulation of interferon-gamma production • MAPK cascade • positive regulation of histone acetylation • positive regulation of gene expression • negative regulation of glucose transport • interleukin-1 beta production • positive regulation of T cell mediated immunity • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of vascular endothelial growth factor production • positive regulation of NF-kappaB import into nucleus • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand • negative regulation of lipid catabolic process • negative regulation of adiponectin secretion • regulation of establishment of endothelial barrier • positive regulation of cell division • signal transduction • positive regulation of transcription from RNA polymerase II promoter • cytokine-mediated signaling pathway • regulation of defense response to virus by host • fever generation • positive regulation of JNK cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3553	16176
Ensembl	ENSG00000125538	ENSMUSG00000027398
UniProt	P01584	P10749
RefSeq (mRNA)	NM_000576	NM_008361
RefSeq (protein)	NP_000567	NP_032387
Location (UCSC)	Chr 2: 112.83 – 112.84 Mb	Chr 2: 129.36 – 129.37 Mb
PubMed search

1HIB, 1I1B, 1IOB, 1ITB, 1L2H, 1S0L, 1T4Q, 1TOO, 1TP0, 1TWE, 1TWM, 21BI, 2I1B, 2KH2, 2NVH, 31BI, 3O4O, 3POK, 41BI, 4DEP, 4G6J, 4G6M, 4GAI, 4I1B, 5I1B, 6I1B, 7I1B, 9ILB, 4GAF, 5BVP

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