Interleukin-20

IL20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DOH
Identifiers
Aliases	IL20, IL-20, IL10D, ZCYTO10, Interleukin 20
External IDs	MGI: 1890473 HomoloGene: 10286 GeneCards: IL20
Gene ontology Molecular function • interleukin-20 receptor binding • receptor binding • cytokine activity • interleukin-22 receptor binding • protein binding Cellular component • extracellular region • extracellular space Biological process • positive regulation of keratinocyte differentiation • positive regulation of osteoclast differentiation • positive regulation of epidermal cell differentiation • regulation of inflammatory response • positive regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50604	58181
Ensembl	ENSG00000162891	ENSMUSG00000026416
UniProt	Q9NYY1	Q9JKV9
RefSeq (mRNA)	NM_018724	NM_021380 NM_001311091
RefSeq (protein)	NP_061194	NP_001298020 NP_067355
Location (UCSC)	Chr 1: 206.87 – 206.87 Mb	Chr 1: 130.91 – 130.91 Mb
PubMed search

4DOH

50604

58181

ENSG00000162891

ENSMUSG00000026416

Q9NYY1

Q9JKV9

NM_018724

NM_021380
NM_001311091

NP_061194

NP_001298020
NP_067355

Interleukin 20 (IL20) is a protein that in humans is encoded by the IL20 gene. Interkeukin 20 also includes other cytokines, including IL-19, IL-20, IL-22, IL-24, and IL-26. Based on common structural and functional properties of IL-20's receptors and target cells, these cytokines constitute the same subfamily, IL-20.

The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

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