Interleukin 10

IL10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24
Identifiers
Aliases	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF, interleukin 10
External IDs	OMIM: 124092 MGI: 96537 HomoloGene: 478 GeneCards: IL10
Genetically Related Diseases
Behcet's disease, ulcerative colitis
Gene ontology Molecular function • protein binding • growth factor activity • cytokine activity • interleukin-10 receptor binding Cellular component • cytoplasm • extracellular region • extracellular space Biological process • negative regulation of chronic inflammatory response to antigenic stimulus • positive regulation of MHC class II biosynthetic process • negative regulation of endothelial cell apoptotic process • hemopoiesis • negative regulation of interferon-gamma production • regulation of sensory perception of pain • positive regulation of B cell apoptotic process • negative regulation of growth of symbiont in host • negative regulation of chemokine (C-C motif) ligand 5 production • response to inactivity • negative regulation of cytokine activity • negative regulation of interleukin-1 production • cellular response to hepatocyte growth factor stimulus • cell-cell signaling • cellular response to estradiol stimulus • negative regulation of interleukin-6 production • positive regulation of cytokine secretion • aging • positive regulation of sequence-specific DNA binding transcription factor activity • negative regulation of interferon-alpha biosynthetic process • negative regulation of apoptotic process • negative regulation of cytokine secretion involved in immune response • response to glucocorticoid • cytoplasmic sequestering of NF-kappaB • negative regulation of interleukin-18 production • negative regulation of MHC class II biosynthetic process • response to activity • response to organic substance • response to carbon monoxide • leukocyte chemotaxis • type 2 immune response • positive regulation of transcription, DNA-templated • negative regulation of myeloid dendritic cell activation • response to insulin • negative regulation of interleukin-8 production • response to lipopolysaccharide • negative regulation of tumor necrosis factor biosynthetic process • B cell proliferation • negative regulation of T cell proliferation • receptor biosynthetic process • negative regulation of nitric oxide biosynthetic process • branching involved in labyrinthine layer morphogenesis • defense response to bacterium • regulation of complement-dependent cytotoxicity • immune response • regulation of gene expression • B cell differentiation • regulation of isotype switching • negative regulation of tumor necrosis factor production • negative regulation of membrane protein ectodomain proteolysis • inflammatory response • cellular response to lipopolysaccharide • response to molecule of bacterial origin • negative regulation of B cell proliferation • negative regulation of inflammatory response • negative regulation of cytokine production • response to drug • positive regulation of transcription from RNA polymerase II promoter • negative regulation of interleukin-12 production • defense response to protozoan • negative regulation of sensory perception of pain • positive regulation of macrophage activation • liver regeneration • regulation of synapse organization • positive regulation of endothelial cell proliferation • negative regulation of cell proliferation • negative regulation of heterotypic cell-cell adhesion • positive regulation of heterotypic cell-cell adhesion • positive regulation of cell cycle • negative regulation of mitotic cell cycle • endothelial cell apoptotic process • regulation of response to wounding • negative regulation of vascular smooth muscle cell proliferation • positive regulation of vascular smooth muscle cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3586	16153
Ensembl	ENSG00000136634	ENSMUSG00000016529
UniProt	P22301	P18893
RefSeq (mRNA)	NM_000572	NM_010548
RefSeq (protein)	NP_000563	NP_034678.1 NP_034678
Location (UCSC)	Chr 1: 206.77 – 206.77 Mb	Chr 1: 131.02 – 131.02 Mb
PubMed search

1ILK, 1INR, 1J7V, 1LK3, 1Y6K, 2ILK, 2H24

3586

16153

ENSG00000136634

ENSMUSG00000016529

P22301

P18893

NM_000572

NM_010548

NP_000563

NP_034678.1
NP_034678

Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor 2 proteins. Consequently, the functional receptor consists of four IL-10 receptor molecules. IL-10 binding induces STAT3 signalling via the phosphorylation of the cytoplasmic tails of IL-10 receptor 1 + IL-10 receptor 2 by JAK1 and Tyk2 respectively.

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